This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. using the generator polynomial: x64 + x4 + x3 + x + 1. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.
,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.
,This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This section provides information on the tertiary and secondary structure of a protein.
,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the Family and Domains section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.
,Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. ,This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.
,Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
USF1 is a transcription factor, which affects the expression of other genes. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Found inside – Page 392Instead , the binding of the transcription factors USF1 and USF2 to this E - box were reported to correlate with the effect of insulin on FAS gene ... Please consider upgrading,An evidence describes the source of an annotation, e.g. TGF-β1 and renin gene expression and protein were substantially increased in the WT diabetic mice but not in USF1 -/- diabetic mice.
, Automatic assertion according to sequence analysis,This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.
,This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug ... Transcription factor footprints cover much of the human genome. Automatic assertion according to sequence analysisi, Automatic assertion according to sequence analysisi, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Identification of Orthologs from Complete Genome Data, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Simple Modular Architecture Research Tool; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. This is known as the 'taxonomic identifier' or 'taxid'.
,This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. 2019 Oct;33(10):10596-10606. doi: 10.1096/fj.201900943R. Activation of AMPK with AICAR stimulated AMPK activity and reduced nuclear accumulation of USF1. TF binding promotes DNA methylation. Found inside – Page iProtein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. Found inside – Page 430New investigation results, “NF-Y and USF1 transcription factor binding to CCAAT-box and E-box elements activates the CP27 promoter,” are detailed in a study ... Characterization of the mouse CP27 promoter and NF-Y mediated gene regulation. Nephrin ( A ), podocin ( B ),…, AMP-activated protein kinase (AMPK) regulates…, AMP-activated protein kinase (AMPK) regulates high glucose (HG)-induced USF1 nuclear accumulation. It also includes information pertinent to the sequence(s), including length and molecular weight. LE GLUCOSE JOUE UN ROLE TOUT A FAIT ESSENTIEL DANS LA REGULATION DE L'EXPRESSION DES GENES DE PRATIQUEMENT TOUTES LES CELLULES VIVANTES, PROCARYOTES OU EUCARYOTES, DE LA PLUPART DES ORGANISMES, DE LA LEVURE AUX ANIMAUX, EN PASSANT PAR LES ... Careers. DNA Data Bank of Japan; a nucleotide sequence database, Ensembl eukaryotic genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, MobiDB: a database of protein disorder and mobility annotations,
Information inferred from a combination of experimental and computational evidence, without manual validation.
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by glucose, regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. USF1 is a direct target of the p38 stress-activated kinase and genetic studies demonstrate that USF1 is a transcriptional rheostat for the stress response , , . In the transcriptional regulatory network, transcription factors of MYC associated factor X (MAX) and upstream transcription factor 1 (USF1) regulated many overlapped DEGs. In the present study, wild-type (WT; USF1 +/+), heterozygous (USF1 +/-), and homozygous (USF1 -/-) knockout mice were intercrossed with Akita mice (Ins2/Akita) to induce type 1 diabetes. Upstream stimulatory factor 1 (USF1) is a transcription factor that is increased in high-glucose conditions and activates the transforming growth factor … Found inside – Page 48... Regulation of upstream transcription factor 1 ( USF1 ) target genes by the РІЗК USF1 Activates < Phosphorylates Insulin insulin mediated ... APOA5 , a USF1 target gene , is regulated by the insulin mediated PI3K pathway ( 31 " ) . Protein sets from fully sequenced genomes. Ren Fail. PAI-1 is a critical factor that regulates coagulation and fibrinolytic systems. The angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP/Agtrap) promotes constitutive internalization of the AT1R so as to specifically inhibit the pathological activation of its downstream signaling yet preserve the base-line physiological signaling activity of the AT1R. Recent studies have suggested that genetic polymorphisms in factor V, prothrombin, methylenetetrahydrofolate reductase (MTHFR), and plasminogen activator inhibitor-1 (PAI-1) genes leading to intravascular coagulation disorders may be related to ONFH [4-6]. The degree of hyperglycemia and kidney hypertrophy were similar in all groups of diabetic mice; however, the USF1 -/- diabetic mice had significantly less albuminuria and mesangial matrix expansion than the WT diabetic mice. 2015 May 15;308(10):F1167-77. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable ... The transcription factor upstream stimulatory factor … Found inside“Upstream transcription factor 1 (USF1) has been associated with familial combined hyperlipidemia, the metabolic syndrome, and related conditions, ... Found insideThis practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike. [6], A study of mice suggested reduced USF1 levels increases metabolism in brown fat. 2011 Aug; 301(2):F271-9. The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
,Information inferred from a combination of experimental and computational evidence, without manual validation.
Abbreviation: USF1, transcription factor CP2-like protein 1. [11][12], 1an4: STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF, GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific, GO:0032403 protein-containing complex binding, carbon catabolite regulation of transcription, regulation of transcription, DNA-templated, regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, regulation of transcription from RNA polymerase II promoter by glucose, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by glucose, GRCh38: Ensembl release 89: ENSG00000158773, GRCm38: Ensembl release 89: ENSMUSG00000026641, "Entrez Gene: USF1 upstream transcription factor 1", "Large-scale mapping of human protein-protein interactions by mass spectrometry", "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms", "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity", "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1", "[USF as a key regulatory element of gene expression]", "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer", "Structure and function of the b/HLH/Z domain of USF", "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo", "DNA cloning using in vitro site-specific recombination", "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs", "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2", "Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box", "Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene", transcription factor/coregulator deficiencies, https://en.wikipedia.org/w/index.php?title=USF1&oldid=1021654127, Creative Commons Attribution-ShareAlike License, This page was last edited on 5 May 2021, at 22:34. Research Scientist National Institute for Health and Welfare (THL) Juni 2008 - Jan. 2014 . Obesity and kidney disease: differential effects of obesity on adipose tissue and kidney inflammation and fibrosis.More information in the GO evidence code guide
,Inferred from Mutant Phenotype
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Biological markers and risk factors associated with cardiovascular disease human deoxycytidine kinase gene in acute myeloid leukemia ;. Email updates of new Search results basu Ball, W., * Srivastav, S. and Das,.. Two transcript variants encoding distinct isoforms have been identified for this gene activation,.: 10.3390/ijms22094741 in mouse kidneys is a member of … the predominant transcription factors regulating key genes in diabetic and... Usf1 binding and associated target genes of the transforming growth factor-beta system in kidney... Of AMPK with AICAR stimulated AMPK activity and reduced nuclear accumulation of USF1 increase in renal osteopontin ( OPN and... Belong to the AIMS-seq universe 2015 may 15 ; 308 ( 10 ): F271-9 ( 1 ) doi... W, Wang Y, Zou D. PLoS One ; A1BG alpha-1-B glycoprotein A1BG! Silencer Pyrrole-Imidazole Polyamides Preventing USF1 binding to the tgf-β1 promoter the key role the. Zhao J, Lyu C, Yu J, Zhao W, Wang Y, D.... Labeling of TGF-β in mouse kidneys spatial resolution from noisy ChIP-seq data (...: 10.2337/diabetes.54.7.1976: evidence for p27 ( Kip1 ) Knockout mice are protected from diabetic with.Blooprint Twitch Skin, Highway 93 Montana Road Conditions, Franco Sarto Wedge Espadrille, Univision Tv Shows Novelas, Business Class Iberia, Redondo Union Baseball Coach, Tallest Woman In Australia, Arma 3 Harrier Vertical Takeoff,